| ABSTRACT | STUDY
DESIGN: A prospective, randomized, double-blind study comparing high-dose
methylprednisolone with placebo. OBJECTIVES: To evaluate the efficacy of
high-dose methylprednisolone when administered within 8 hours after whiplash injury.
SUMMARY OF BACKGROUND DATA: Whiplash injury often results in chronic symptoms.
The management of whiplash injuries is controversial, and pharmacologic therapy
has received little evaluation. In recent reports, dysfunction of the central
nervous system has been indicated in several cases. Methylprednisolone administered
within 8 hours after the injury to patients with acute spinal cord injury has
been demonstrated to improve the outcome. This procedure was also adopted in a
randomized study of cases of whiplash injury in car accidents. METHODS:
Forty patients, 22 men and 18 women with a mean age of 35 years (range, 19-65),
were included in the study, 20 in each of two groups. They were treated for whiplash
injury, which they had sustained in car accidents. The patients were enrolled
if their diagnoses were complete and treatment had begun within 8 hours after
injury. Disabling symptoms severe enough to prevent the patient from returning
to work, number of sick days before and after injury, and sick-leave profile after
injury were used as parameters for the evaluation of the effects of the treatment.
Baseline demographic data were controlled for when statistical analysis had been
performed. RESULTS: At the follow-up examination 6 months after initial
treatment, there was a significant difference in disabling symptoms between the
actively treated patients and the placebo group (P = 0.047), total number of sick
days (P = 0.01), and sick-leave profile (P = 0.003). CONCLUSIONS: The results
of this study indicate that acute treatment with high-dose methylprednisolone
may be beneficial in preventing extensive sick leave after whiplash injury. However,
the number of patients studied was small, and therefore further prospective, controlled
studies are needed. |