RED FLAGS

SUMMARY: Safety has greater priority than accuracy in the process of diagnosis. In addition to in the diagnosis of atypical illness, clinicians are intrinsically error-prone unless they proactively adopt protective strategies. Red Flags have been developed for abdominal pain, both in children and in suspected Irritable Bowel Syndrome, headache, back pain, eye pain and rashes.

If adverse outcomes of diagnostic errors are to be reduced, clinicians need to give safe diagnosis greater priority than accurate diagnosis.

Such "diagnosis by pay-off" 1 may be inimical to some purist medical teachers. Nevertheless, the "accurate diagnosis" approach results in Necessary Fallibility.  The problem is that "textbook cases" of illness are the exception rather than the rule, there are usually atypical features, and some clinical presentations are so extremely unusual as to be diagnostically misleading - this animal looks more like a cat but it is actually a dog. 

Particularly in medical emergency situations, it is at least as important to know what the diagnosis is not as what it is.  Such Diagnosis by Exclusion may be intellectually unsatisfying and leave both patient and physician feeling insecure, but "chest pain Not Yet Diagnosed, but unstable angina and coronary thrombosis excluded" is much safer than "probably muscular".  Indeed, the unsatisfying and insecure nature of the uncertain diagnosis leaves patient and future caregivers appropriately open to refining the diagnosis in light of subsequent developments.  Conversely, allocating to an illness a working diagnosis or label for which there is only symptomatic treatment discourages the patient from seeking further help when symptoms change or worsen. 

In addition to Necessary Fallibility in the diagnosis of atypical illness, clinicians are intrinsically error-prone unless they proactively adopt protective strategies.

Not only are clinicians prone to premature closure in the diagnostic process, but subsequent caregivers are liable to adopt uncritically a previous diagnosis that a patient reports to them.  It is essential for patient safety that physicians attempt actively to disprove the diagnoses they make intuitively, particular in the Emergency Department 2.[]

"Red Flags" are a useful aide-memoire for a limited variety of common conditions.  These are exclusionary criteria that alert clinicians to emergency, life-threatening or serious diagnoses for which there is potential for cure or amelioration, usually within a limited window of opportunity

Medicolegal Implications

Red Flags have been developed for abdominal pain, both in children and in suspected Irritable Bowel Syndrome headache, back pain, eye pain and rashes.

In the event of adverse outcome of diagnostic error, medical malpractice Plaintiff counsel should look for documentary evidence that "red flags" were considered. 

Abdominal Pain

Practical Pointer

Red flags 3 [] 4 [] in suspected Irritable Bowel Syndrome

  • History
    • Onset after age 50
    • Persistent diarrhea or severe constipation
    • Rectal bleeding
    • Weight loss
    • Fever
    • Symptoms at night
    • Recent antibiotic use
  • Family history of colon cancer or Inflammatory Bowel Disease
  • Examination
    • Fever
    • Swelling on abdominal or rectal examination
  • Investigations
    • Anemia
    • Blood on testing stools

Practical Pointer

Red flags [] for suspecting a physical cause of recurrent abdominal pain in childhood

  • History
    • Pain away from the navel
    • Awakening child at night
    • Fever
    • Weight loss
    • Change in bowel function
    • Painful urination
  • Investigations

Headache

Practical Pointer

Red flags 5 for headache

  • History
    • new onset, particularly in middle age or beyond
    • change of pattern
    • pain with effort or position
    • recent head trauma
  • Past history of chronic serious illness
  • Change in personality or behaviour
  • Examination
    • fever
    • neck stiffness
    • neurological findings

Back Pain

Practical Pointer

Red flags [] for low back pain

  • History
    • cancer
    • unexplained weight loss
    • fever
    • recent infection
    • immunosuppression
    • intravenous drug use
    • pain when supine or severe at night
    • trauma: major in young, minor in elderly
  • Neurological
    • bladder control
    • bowel control
    • loss of "saddle" or leg sensation
    • severe/progressive leg weakness
  • Examination
    • anal sphincter weak
    • major leg weakness
    • loss of anal or "saddle" sensation

Eye Pain

Practical Pointer

Red flags 6 in painful eye

Rash

Practical Pointer

Red[ ] flags for urgent diagnosis of a rash

  • History
  • Vital signs
    • Fever
    • Low blood pressure
  • Appearance
    • Toxic-looking
    • Erythroderma (Diffuse redness)
    • Swollen lymph-nodes
    • Petechiae or purpura (bleeding into skin)
    • Mucosal (lining of orifices) including mouth
    • Severe localised pain/tenderness of extremity

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